RESEARCH AREAS

Single-Cell Antibody Sequencing Technologies

Healthy and Aberrant Antibody Development

HIGHLIGHTED PUBLICATIONS

Applying high-throughput technologies to engineer a potent antibody drug for malaria protection.

New antibodies against malaria

Highly protective anti-malarial antibodies via precision yeast display library generation and screening.

Banach BB, Tripathi P, Pereira L, Gorman J, Nguyen TD, Dillon M, Fahad AS, Kiyuka P, Madan B, Wolfe JR, Bonilla B, Flynn B, Francica JR, Hurlburt NK, Liu T, Ou L, Rawi R, Schön A, Shen C-H, Teng I-T, Zhang B, Pancera M, Idris AH, Seder RA, Kwong PD, DeKosky B

Journal of Experimental Medicine, 219:8, 2022 DOI: 10.1084/jem.20220323 PMID: 35736810

Antibodies Computational immunology Drug discovery Infectious diseases Malaria
Understanding potent immunity against HIV-1

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.

Madan, B., Zhang, B., Xu, K., Chao, C. W., O’Dell, S., Wolfe, J. R., Chuang, G.-Y., Fahad, A. S., Geng, H., Kong, R., Louder, M. K., Nguyen, T. D., Rawi, R., Schön, A., Sheng, Z., Nimrania, R., Wang, Y., Zhou, T., Lin, B. C., Doria-Rose, N. A., Shapiro, L., Kwong, P. D. & DeKosky, B. J.

Proceedings of the National Academy of Sciences of the USA, 2021

Antibodies Computational immunology Drug discovery HIV-1 Immune development Infectious diseases
Understanding the ways that antibody responses can contribute to COVID-19.

Studying the mechanisms driving severe COVID-19

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Lee, W. S., Wheatley, A. K., Kent, S. J. & DeKosky, B. J.

Nature Microbiology, 5: 1185–1191, 2020 DOI: 10.1038/s41564-020-00789-5 PMID: 32908214

Antibodies COVID-19 Immune development Infectious diseases
A new approach to immortalize human antibody immune responses for functional screening and drug discovery.

Advancing techniques to study antibody immunity

Functional Interrogation and Mining of Natively-Paired VH:VL Human Antibody Repertoires

Wang B*, DeKosky BJ*, Timm MR, Lee J, Normandin E, Misasi J, Kong R, McDaniel JR, Delidakis G, Leigh KE, Niezold T, Choi CW, Viox EG, Fahad A, Cagigi A, Ploquin A, Leung K, Yang ES, Kong W-P, Voss WN, Schmidt AG, Moody MA, Ambrozak DR, Henry AR, Laboune F, Ledgerwood JE, Graham BS, Connors MR, Douek DC, Sullivan NJ, Ellington AD, Mascola JR**, Georgiou G**

Nature Biotechnology, 36: 152–155, 2018 DOI: 10.1038/nbt.4052 PMID: 29309060

Antibodies Computational immunology Drug discovery HIV-1 Immune development Infectious diseases Single-cell technologies

RECENT NEWS

September 2022

The lab just received a major Bill and Melinda Gates Foundation project to improve anti-malaria antibodies for low-cost solutions toward malaria eradication. Many thanks to Gates Foundation for this exciting partnership, and we are excited to get started!

August 2022

Oscar, Eli, Lakisha, and Donovan all make their final presentations on their summer projects. Great work this summer!
August 2022

Oscar, Eli, Lakisha, and Donovan all make their final presentations on their summer projects. Great work this summer!
August 2022

Oscar, Eli, Lakisha, and Donovan all make their final presentations on their summer projects. Great work this summer!
August 2022

Oscar, Eli, Lakisha, and Donovan all make their final presentations on their summer projects. Great work this summer!
August 2022

Oscar, Eli, Lakisha, and Donovan all make their final presentations on their summer projects. Great work this summer!